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Spravato® Therapy

A prescription, FDA-approved nasal spray used to treat depression and suicidal ideation.


Is Spravato covered by insurance? Many insurance companies cover Spravato. Find out more here.

Will I pay out of pocket? 

Most insurances cover the full cost of the medicine, but you will be liable for a payment of $150 per treatment for the monitoring.  There is financial help for this portion. 

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What is SPRAVATO®?

Spravato® (esketamine intranasal) is a prescription, FDA-approved nasal spray made up of the chemical esketamine, which is made from ketamine, an anesthetic drug that is also used to treat depression at subanesthetic doses. When used in conjunction with an oral antidepressant, Spravato can provide relief from treatment resistant major depression and depression with suicidal thoughts within hours of using it.

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How will I benefit from SPRAVATO®?

You will take SPRAVATO® nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting. Your healthcare provider will show you how to use the SPRAVATO® nasal spray device.

Your healthcare provider will tell you how much SPRAVATO® you will take and when you will take it.

Follow your SPRAVATO® treatment schedule exactly as your healthcare provider tells you to.

During and after each use of the SPRAVATO® nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.

You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO®.

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Who should not use SPRAVATO®

Spravato is not approved for use by children. You should not take Spravato if you are allergic to esketamine, a similar medicine called ketamine used for anesthesia, or any of the other ingredients in SPRAVATO®. You should not take Sopravato if you have a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation) or a history of bleeding in the brain.

Be sure to tell your healthcare provider if you have heart, brain or liver problems; if you have psychosis; or if you are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed. You should not take SPRAVATO® if you are pregnant. You should not breastfeed if you are taking SPRAVATO®.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

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Does SPRAVATO® replace my Current Antidepressant?

No. Spravato should be taken in conjunction with an oral antidepressant. Insurance companies require a patient to be prescribed an oral antidepressant prior to approving treatment coverage. Spravato is intended to supplement but not replace your current anti-depression treatment.

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Are there any restirctions on eating and drinking on my SPRAVATO® treatment days? 

Some patients taking SPRAVATO® may experience nausea or vomiting. Because of this, you should avoid eating two hours before, and drinking liquids 30 minutes before, taking SPRAVATO®.


Who will benefit from SPRAVATO®?

Spravato is for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD), including those experiencing suicidal thoughts.

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